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KMID : 0043319970200020110
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Archives of Pharmacal Research
1997 Volume.20 No. 2 p.110 ~ p.114
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Cytotoxic activities of various fractions extracted from some pharmaceutical insect relatives
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Huang Yao-Ge
Kang Jong-Koo
Liu Ren-Song
Oh Ki-Wan
Nam Chun-Ja
Kim Hack-Seang
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Abstract
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This research was performed to screen the cytotoxic activities of some pharmaceutical insect relatives. Cytotoxic activities of total extract and fractions of hexane, ethyl acetate, methanol, water and boiling water were extracted from four pharmaceutical insect relatives: the Chinese gall, the cicada slough, the hornet nest and the batryticated silkworm. These extracts were investigated against the cancer cell lines of L1210, P388 and SNU-1 in vitro tests. Results showed that, ED, , against the cancer cell lines of L1210, P388 and SNU-1 were 0.55, 0.50, and in the ethyl acetate fraction from the Chinese gall; 1.07, 2.19, and in the ethyl acetate fraction, 1.51, 1.26, and in the water fraction and 1.48, 2.29, and in the boiling water fraction from the cicada slough; 3.31, 2.00, and in the water fraction from the hornet nest and 13.80, 19.95, and in the hexane fraction and 33.88, 21.88, and in the ethyl acetate fraction from the batryticated silkworm, respectively. All of the fractions mentioned above showed high cytotoxic activities and could be suggested for further studies in vivo tests.
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KEYWORD
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Cytotoxic activitirs, Pharmaceutical insects, Chinese gall, Cicada slough, Hornetnest, Batryticated silkworm, Cancer cell lines (L1210, P388 and SNU-1)
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